Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.66 |
| ▸ | LMNA | P02545 | 10/20 | 0.66 |
| ▸ | HTT | P42858 | 9/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.62 |
| ▸ | G6PD | P11413 | 2/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.62 |
| ▸ | MEN1 | O00255 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378751 | 0.89 | MAPT (0.66) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL11598567 | 0.82 | LMNA (0.65) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL12670563 | 0.82 | MAPT (0.67) | MAPTLMNAHTTNPSR1TP53 | |
| E324 SCHEMBL10356767 | 0.81 | ALDH1A1 (0.85) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL12633824 | 0.81 | MAPT (0.66) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL12633826 | 0.81 | MAPT (0.62) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL12671045 | 0.79 | MAPT (0.66) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL12633828 | 0.79 | MAPT (0.64) | MAPTLMNAHTTNPSR1TP53 | |
| SCHEMBL12633827 | 0.79 | MAPT (0.64) | MAPTLMNAHTTNPSR1TP53 | |
| E324 SCHEMBL9767913 | 0.79 | ALDH1A1 (0.85) | MAPTLMNAHTTNPSR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527817-B2 | Compounds for treating peripheral; neuropathies and other neurodegenerative; disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-12-27 | — | — | US | disclosed |
| US-20140303203-A1 | COMPOUNDS FOR TREATING PERIPHERAL; NEUROPATHIES AND OTHER NEURODEGENERATIVE; DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-10-09 | — | — | US | disclosed |
| WO-2012177831-A2 | COMPOUNDS FOR TREATING PERIPHERAL NEUROPATHIES AND OTHER NEURODEGENERATIVE DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303203-A1 | COMPOUNDS FOR TREATING PERIPHERAL; NEUROPATHIES AND OTHER NEURODEGENERATIVE; DISORDERS | HSP90AB1, HSP90AA1, HSP90AB2P | MAPT 43/4885LMNA 3007/4885HTT 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.