Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of E324. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.85 |
| ▸ | LMNA | P02545 | 10/20 | 0.85 |
| ▸ | HPGD | P15428 | 7/20 | 0.85 |
| ▸ | MEN1 | O00255 | 7/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.85 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.85 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.85 |
| ▸ | MAPT | P10636 | 17/20 | 0.55 |
| ▸ | HTT | P42858 | 10/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E324 SCHEMBL10356767 | 0.95 | ALDH1A1 (0.85) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL27577579 | 0.94 | ALDH1A1 (0.82) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL10356327 | 0.94 | ALDH1A1 (0.82) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL28303511 | 0.92 | ALDH1A1 (0.94) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL29357397 | 0.92 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL21601 | 0.92 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL7999894 | 0.92 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL28310950 | 0.91 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL9767911 | 0.91 | ALDH1A1 (0.92) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| E324 SCHEMBL27685174 | 0.91 | ALDH1A1 (0.92) | ALDH1A1KDM4ELMNAHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061815-A | Dietary supplementation | ZINPRO CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |