Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821527 | 0.82 | NPSR1 (0.63) | PKMNPSR1MAPK1PAX8ATM | |
| SCHEMBL1821065 | 0.82 | MAPK1 (0.43) | PKMNPSR1MAPK1PAX8ATM | |
| SCHEMBL13791595 | 0.79 | NPSR1 (0.75) | PKMNPSR1MAPK1PAX8ATM | |
| SCHEMBL13065100 | 0.75 | LOXL2 (0.40) | PKMNPSR1MAPK1PAX8ATM | |
| SCHEMBL12656711 | 0.72 | SMN1; SMN2 (0.60) | PKMNPSR1MAPK1ATMMAPT | |
| SCHEMBL12656928 | 0.72 | HTT (0.44) | MAPK1PAX8MAPTPOLBNPC1 | |
| SCHEMBL14409077 | 0.72 | KMT2A (0.57) | MAPK1NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL12657084 | 0.72 | GLS (0.44) | MAPK1MAPTPOLBNPC1RAB9A | |
| SCHEMBL12656688 | 0.72 | SMN1; SMN2 (0.56) | NPSR1NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL12656927 | 0.71 | RAB9A (0.41) | PKMNPSR1MAPK1PAX8ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271179-B2 | Inhibitors of JAK protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-18 | — | — | US | disclosed |