Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22266161 | 0.84 | KCNH2 (0.62) | ADRA2CKMT2AHTR1ALMNADRD2 | |
| SCHEMBL6152013 | 0.84 | MAPT (0.59) | GFERKDM4EMAPTGAARAD52 | |
| SCHEMBL1364675 | 0.84 | MAPT (0.59) | GFERKDM4EMAPTGAARAD52 | |
| SCHEMBL188852 | 0.84 | MAPT (0.62) | GFERKDM4EMAPTGAARAD52 | |
| SCHEMBL6150880 | 0.84 | MAPT (0.62) | GFERKDM4EMAPTGAARAD52 | |
| SCHEMBL6151437 | 0.84 | MAPT (0.62) | GFERKDM4EMAPTGAARAD52 | |
| SCHEMBL1809859 | 0.83 | KDM4E (0.63) | GFERKDM4EMAPTGAARAD52 | |
| SCHEMBL27937113 | 0.83 | HTR1A (0.48) | KDM4EALDH1A1ADRA2CKMT2ABCL2A1 | |
| SCHEMBL14204012 | 0.82 | LTA4H (0.61) | ALDH1A1KMT2AHTR1ADRD3CYP2D6 | |
| SCHEMBL9354477 | 0.81 | ALDH1A1 (0.53) | KDM4ESMN1; SMN2ALDH1A1ADRA2CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014183300-A1 | VEGFR TYROSINE KINASE INHIBITORS | SUZHOU VIVOTIDE BIOTECHNOLOGIES CO., LTD. (CN) | 2014-11-20 | — | — | WO | disclosed |
| EP-1567522-B1 | PYRIMIDINE COMPOUNDS | CYCLACEL LTD (GB) | 2007-09-19 | — | — | EP | disclosed |