Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 9/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12668376 | 0.87 | SMN1; SMN2 (0.77) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL5195426 | 0.84 | SMN1; SMN2 (1.00) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL13873283 | 0.83 | EPHX2 (1.00) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL8361624 | 0.82 | SMN1; SMN2 (0.97) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL491293 | 0.81 | KMT2A (1.00) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL25994889 | 0.81 | EPHX2 (0.80) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL14413644 | 0.80 | EPHX2 (0.75) | SMN1; SMN2EPHX2KMT2AMEN1MAPT | |
| SCHEMBL25855522 | 0.80 | RAB9A (0.72) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL311835 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2EPHX2KMT2ARAB9ANPC1 | |
| SCHEMBL4559572 | 0.79 | SMN1; SMN2 (0.91) | SMN1; SMN2KMT2ARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007106705-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-09-20 | — | — | WO | disclosed |