Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14415582 | 1.00 | PNMT (0.55) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL14415581 | 1.00 | PNMT (0.55) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6348596 | 0.79 | SLC6A2 (0.41) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL2032469 | 0.78 | ADRB2 (0.54) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL30504213 | 0.78 | ADRB2 (0.54) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL382596 | 0.78 | ADRB2 (0.54) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL148751 | 0.78 | ADRB2 (0.54) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL13666761 | 0.78 | ADRB2 (0.54) | PNMTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6001243 | 0.78 | IDO1 (0.46) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| Hydrochloric Acid SCHEMBL4559164 | 0.78 | IDO1 (0.50) | OPRK1SLC6A2SLC6A3SLC6A4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268166-B2 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases | NPS PHARMACEUTICALS, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268166-B2 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases | NPS PHARMACEUTICALS, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1749522-A2 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases | NPS PHARMACEUTICALS, INC. (US) | 2007-02-07 | — | — | EP | disclosed |