SCHEMBL14416559

SCHEMBL14416559

COC(=O)NCc1ccc(-c2cc(C(=O)NC(C)(C)C)nn2-c2cccnc2)nc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.47
CNR2 P34972 1/20 0.47
DHODH Q02127 2/20 0.44
MARS1 P56192 1/20 0.41
KDM4E B2RXH2 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
MMP13 P45452 1/20 0.39
TSHR P16473 1/20 0.39
CACNA1G O43497 1/20 0.39
CACNA1H O95180 1/20 0.39
RECQL P46063 1/20 0.39
NAMPT P43490 1/20 0.39
SLC16A3 O15427 1/20 0.38
SLC16A1 P53985 1/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
MEN1 O00255 1/20 0.38
NPC1 O15118 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5522940 0.93 NAMPT (0.47) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL5526417 0.91 CNR1 (0.48) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL5525413 0.91 CNR1 (0.48) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL5526193 0.89 CNR1 (0.50) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL14416565 0.89 MARS1 (0.51) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL5526175 0.87 CNR1 (0.54) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL5525714 0.87 CNR1 (0.51) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL5526762 0.86 CNR1 (0.47) CNR1CNR2DHODHMARS1KDM4E
SCHEMBL5526640 0.86 CNR1 (0.47) CNR1CNR2DHODHMARS1KDM4E
Hydrochloric Acid SCHEMBL5520798 0.86 CNR1 (0.50) CNR1CNR2DHODHMARS1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070219210-A1 Amidopyrazole Derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-09-20 US disclosed
US-20070219210-A1 Amidopyrazole Derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219210-A1 Amidopyrazole Derivative PTGER1, PTGS1, PTGER2 CNR1 76/4885CNR2 43/4885DHODH 1894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.