Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9114685 | 0.99 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL9117437 | 0.89 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL9116063 | 0.89 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL1442749 | 0.89 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL9117394 | 0.89 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL3658257 | 0.87 | HTT (0.70) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL9117204 | 0.87 | NPC1 (0.58) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL3663202 | 0.87 | HTT (0.70) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL3658080 | 0.87 | HTT (0.70) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL3658608 | 0.87 | HTT (0.70) | NPC1RAB9AKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546402-B2 | Chromone derivatives, a process for their preparation and their therapeutic applications | SOKOLOFF PIERRE (FR) | 2013-10-01 | — | — | US | disclosed |
| EP-2470520-B1 | CHROMONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS | PF MEDICAMENT (FR) | 2013-07-17 | — | — | EP | disclosed |
| EP-2470520-A1 | CHROMONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS | Pierre Fabre Medicament (FR) | 2012-07-04 | — | — | EP | disclosed |
| US-20120157463-A1 | CHROMONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS | PIERRE FABRE MEDICAMENT (FR) | 2012-06-21 | — | — | US | disclosed |
| WO-2011027289-A1 | CHROMONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS | PIERRE FABRE MEDICAMENT (FR) | 2011-03-10 | — | — | WO | disclosed |
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |
| WO-1995025731-A1 | NOVEL 3-(φ-(4-BENZOYLPIPERIDINO)ALKYL)-4H-BENZOPYRAN-4-ONES, PREPARATION AND THERAPEUTICAL USE THEREOF | PIERRE FABRE MEDICAMENT (FR) | 1995-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157463-A1 | CHROMONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS | CHRNA3, CHRM3, VDR | NPC1 1370/4885RAB9A 2058/4885KMT2A 3560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.