Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.46 |
| ▸ | ATF1 | P18846 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422196 | 0.83 | NPC1 (0.46) | NFKB1NPC1RAB9AMAPTPOLB | |
| SCHEMBL14422228 | 0.79 | LMNA (0.56) | TRPV1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL14422195 | 0.79 | AHR (0.65) | AHRNPC1MAPTKDM4EPOLB | |
| SCHEMBL14422198 | 0.77 | TRPV1 (0.48) | TRPV1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL5215834 | 0.74 | KDM4E (0.42) | NFKB1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL14422204 | 0.72 | TRPV1 (0.46) | TRPV1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL12590829 | 0.71 | GRM4 (0.56) | KCNJ5KCNJ3RAB9ATMPRSS4MAPT | |
| SCHEMBL14770779 | 0.71 | GRM4 (0.56) | KCNJ5KCNJ3RAB9ATMPRSS4MAPT | |
| SCHEMBL4533924 | 0.71 | TRPV1 (0.54) | TRPV1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL14422226 | 0.70 | RORC (0.54) | NPC1RAB9AMAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |