Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422228 | 0.80 | LMNA (0.56) | MAPTKMT2ANR1H4ALDH1A1NPC1 | |
| SCHEMBL14422197 | 0.79 | TRPV1 (0.47) | AHRMAPTMEN1KMT2ANPC1 | |
| SCHEMBL5216624 | 0.76 | SMN1; SMN2 (0.54) | MAPTKMT2ANR1H4ALDH1A1NPC1 | |
| SCHEMBL5213978 | 0.75 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL14422204 | 0.73 | TRPV1 (0.46) | AHRMAPTNPC1LMNA | |
| SCHEMBL14422198 | 0.71 | TRPV1 (0.48) | NPC1 | |
| SCHEMBL14422231 | 0.71 | LMNA (0.56) | MAPTKMT2AALDH1A1NPC1GAA | |
| SCHEMBL5215713 | 0.71 | ALDH1A1 (0.34) | AHRPPARAALDH1A1NPC1GAA | |
| SCHEMBL14422226 | 0.71 | RORC (0.54) | MAPTKMT2AALDH1A1NPC1GAA | |
| SCHEMBL3117820 | 0.70 | TRPV1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |