Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422661 | 0.81 | PIM1 (0.68) | PIM1HSD17B10POLBMAPTMALT1 | |
| SCHEMBL14422770 | 0.79 | PIM1 (0.53) | PIM1HPGDSMN1; SMN2RAB9ATSHR | |
| SCHEMBL14422651 | 0.79 | PIM1 (0.64) | PIM1MALT1CDK2JAK2IRAK4 | |
| SCHEMBL14422647 | 0.78 | PIM1 (1.00) | PIM1HSD17B10POLBMAPTCDK2 | |
| SCHEMBL14422676 | 0.78 | PIM1 (1.00) | PIM1HPGDTSHRHSD17B10POLB | |
| SCHEMBL14422681 | 0.77 | PIM1 (1.00) | PIM1HSD17B10POLBMAPTCDK2 | |
| SCHEMBL1772796 | 0.76 | TSHR (0.50) | PIM1HPGDSMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL14422668 | 0.74 | PIM1 (1.00) | PIM1HSD17B10POLBMAPTMALT1 | |
| SCHEMBL1054983 | 0.73 | FYN (0.70) | PIM1 | |
| SCHEMBL5618964 | 0.73 | PIM1 (0.92) | PIM1HSD17B10POLBMAPTCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268136-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-11 | — | — | US | disclosed |