Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14424663 | 0.85 | GAA (0.47) | TRPV1RAB9AMAPTXBP1NPSR1 | |
| SCHEMBL14424840 | 0.84 | LSS (0.57) | HDAC3HDAC8HDAC6EPHX2 | |
| SCHEMBL14424320 | 0.81 | PTPN1 (0.59) | TRPV1NPC1RAB9AMAPTNPSR1 | |
| SCHEMBL14424416 | 0.81 | KDM4E (0.45) | NPC1RAB9AKCNQ3KCNQ2KCNE1 | |
| SCHEMBL7513604 | 0.81 | TRPV1 (0.83) | TRPV1PTGS1NPC1RAB9ARORC | |
| SCHEMBL14424661 | 0.80 | RAB9A (0.41) | TRPV1NPC1RAB9ATRPV4MAPT | |
| SCHEMBL14424319 | 0.78 | MAPT (0.50) | NPC1RAB9AMAPTHDAC8HDAC6 | |
| SCHEMBL15948139 | 0.76 | TRPV1 (0.76) | TRPV1PTGS1NPC1RAB9ARORC | |
| SCHEMBL8363736 | 0.76 | NPC1 (0.76) | TRPV1PTGS1NPC1RAB9ARORC | |
| SCHEMBL13716566 | 0.76 | MAPT (0.65) | NPC1RAB9AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |