Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.86 |
| ▸ | MAPT | P10636 | 2/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451560 | 0.72 | TSHR (0.75) | TSHRNPSR1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL316185 | 0.72 | ALDH1A1 (0.76) | TSHRNPSR1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL6211216 | 0.72 | KMT2A (0.67) | TSHRNPSR1MAPTKMT2AMEN1 | |
| SCHEMBL3636891 | 0.72 | GHSR (0.75) | TSHRNPSR1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL10333070 | 0.71 | TSHR (1.00) | TSHRMAPTKMT2AMEN1LMNA | |
| SCHEMBL28163452 | 0.71 | NPC1 (0.68) | TSHRNPSR1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL8722344 | 0.71 | TSHR (0.73) | TSHRNPSR1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL10333068 | 0.71 | TSHR (0.73) | TSHRSMN1; SMN2MAPTKMT2ALMNA | |
| SCHEMBL3554810 | 0.69 | GPBAR1 (0.72) | TSHRMAPTKMT2ALMNAGPBAR1 | |
| SCHEMBL11894104 | 0.69 | POLB (0.77) | TSHRMAPTKMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203224-A1 | SMALL-MOLECULES FOR TREATING CANCER AND ABNORMAL CELL PROLIFERATION DISORDERS | UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-08-30 | — | — | US | disclosed |
| US-20070203224-A1 | SMALL-MOLECULES FOR TREATING CANCER AND ABNORMAL CELL PROLIFERATION DISORDERS | UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-08-30 | — | — | US | disclosed |
| WO-2007081966-A2 | SMALL MOLECULES FOR TREATING CANCER AND ABNORMAL CELL PROLIFERATION DISORDERS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2007-07-19 | — | — | WO | disclosed |