SCHEMBL316185

SCHEMBL316185

Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)O

nearest known ligand 0.76

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.76
MAPT P10636 4/20 0.76
GAA P10253 2/20 0.76
LMNA P02545 2/20 0.76
TSHR P16473 2/20 0.75
PTGS2 P35354 2/20 0.68
L3MBTL1 Q9Y468 2/20 0.66
KDM4E B2RXH2 2/20 0.65
TDP1 Q9NUW8 2/20 0.65
KMT2A Q03164 3/20 0.61
GPBAR1 Q8TDU6 1/20 0.61
GLA P06280 1/20 0.60
PKM P14618 1/20 0.60
HPGD P15428 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
NPSR1 Q6W5P4 2/20 0.57
MEN1 O00255 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12457296 0.92 TSHR (0.69) ALDH1A1MAPTGAALMNATSHR
SCHEMBL899628 0.90 LMNA (0.68) ALDH1A1MAPTGAALMNATSHR
SCHEMBL12273387 0.87 PTGS2 (0.61) ALDH1A1MAPTGAALMNATSHR
SCHEMBL3451560 0.87 TSHR (0.75) ALDH1A1MAPTGAALMNATSHR
SCHEMBL10333070 0.86 TSHR (1.00) ALDH1A1MAPTGAALMNATSHR
SCHEMBL10333068 0.86 TSHR (0.73) ALDH1A1MAPTGAALMNATSHR
SCHEMBL8722344 0.86 TSHR (0.73) ALDH1A1MAPTGAALMNATSHR
SCHEMBL30395456 0.84 HSD17B10 (0.76) ALDH1A1MAPTLMNAL3MBTL1GPBAR1
SCHEMBL459354 0.84 HSD17B10 (0.76) ALDH1A1MAPTLMNAL3MBTL1GPBAR1
SCHEMBL6069726 0.84 ALDH1A1 (0.55) ALDH1A1MAPTGAALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113614290-B Nickel or nickel alloy electroplating bath for depositing semi-bright nickel or semi-bright nickel alloy coatings 德国艾托特克公司 2024-09-27 CN claimed
CN-113699567-B Ultrathin plating electroplating method applied to neodymium iron boron surface treatment 杭州象限科技有限公司 2022-08-26 CN claimed
EP-1745009-B1 HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES GRUENENTHAL GMBH (DE) 2012-11-14 EP claimed
US-7820705-B2 Compounds and compositions as PPAR modulators IRM LLC (BM) 2010-10-26 US claimed
US-20090286833-A1 Substituted Cyclohexylmethyl Compounds GRUENENTHAL GMBH (DE) 2009-11-19 US claimed
JP-2007536321-A 2007-12-13 JP claimed
US-20070129369-A1 Heteroaryl substituted cyclohexyl-1,4-diamine compounds GRUENENTHAL GMBH (DE) 2007-06-07 US claimed
EP-1745009-A1 HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES Grünenthal GmbH (DE) 2007-01-24 EP claimed
WO-2005110971-A1 HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES Grünenthal GmbH (DE) 2005-11-24 WO claimed
US-4007168-A Process for preparing penicillins derivatives PALOMO COLL A L 1977-02-08 US claimed
CN-120099597-A Nickel pre-plating additive suitable for high area and electroplating method 江苏威金迈科技有限公司 2025-06-06 CN disclosed
US-20250051950-A1 ALKALINE COMPOSITION FOR COPPER ELECTROPLATING COMPRISING A DEFECT REDUCTION AGENT BASF SE (DE) 2025-02-13 US disclosed
EP-4457390-A1 ALKALINE COMPOSITION FOR COPPER ELECTROPLATING COMPRISING A DEFECT REDUCTION AGENT BASF SE (DE) 2024-11-06 EP disclosed
CN-118320166-B Wound dressing and preparation method thereof 四川大学 2024-10-29 CN disclosed
CN-113614290-B Nickel or nickel alloy electroplating bath for depositing semi-bright nickel or semi-bright nickel alloy coatings 德国艾托特克公司 2024-09-27 CN disclosed
CN-1208416-A Isooxacephem derivatives HOFFMANN LA ROCHE (CH) 1999-02-17 CN disclosed
EP-0879237-A1 ISOOXACEPHEM DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1998-11-25 EP disclosed
US-5811419-A ANTIBIOTICS HOFFMANN-LA ROCHE INC. (US) 1998-09-22 US disclosed
WO-1997026260-A1 ISOOXACEPHEM DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1997-07-24 WO disclosed
US-4230849-A Process for the activation of carboxylic acids ANTIBIOTICOS, S.A. (ES) 1980-10-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070129369-A1 Heteroaryl substituted cyclohexyl-1,4-diamine compounds DDC, DPYD, PKD1 ALDH1A1 119/4885MAPT 1757/4885GAA 24/4885
US-20090286833-A1 Substituted Cyclohexylmethyl Compounds CNR1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1R ALDH1A1 1333/4885MAPT 2278/4885GAA 448/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.