SCHEMBL14432142

SCHEMBL14432142

Cc1cc(C)c(-c2c(O)sc(-c3ccccc3)nc2=O)cc1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.41
ALOX5 P09917 1/20 0.40
HPGD P15428 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TRPM8 Q7Z2W7 3/20 0.39
CDC7 O00311 1/20 0.39
DBF4 Q9UBU7 1/20 0.39
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
RARA P10276 1/20 0.37
RARB P10826 1/20 0.37
RARG P13631 1/20 0.37
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
POLB P06746 1/20 0.36
RAB9A P51151 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14432231 0.87 TRPM8 (0.41) ALDH1A1ALOX5TRPM8GAAMAPT
SCHEMBL812067 0.83 ALDH1A1 (0.48) ALDH1A1MEN1KMT2ASMN1; SMN2ALOX5
SCHEMBL7804643 0.83 ALDH1A1 (0.48) ALDH1A1MEN1KMT2ASMN1; SMN2ALOX5
SCHEMBL13527170 0.82 ALDH1A1 (0.47) ALDH1A1MEN1KMT2ASMN1; SMN2ALOX5
SCHEMBL9883892 0.80 TRPM8 (0.46) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL10309270 0.77 ALDH1A1 (0.42) ALDH1A1MEN1KMT2ASMN1; SMN2ALOX5
SCHEMBL15450056 0.76 CDC7 (0.45) ALDH1A1MEN1KMT2ASMN1; SMN2TRPM8
SCHEMBL8989405 0.73 TRPM8 (0.36) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL13002660 0.73 PIK3CD (0.39) ALDH1A1MEN1KMT2ASMN1; SMN2NPSR1
SCHEMBL12270067 0.72 MEN1 (0.39) ALDH1A1MEN1KMT2AALOX5TRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7256158-B2 2,4,5,-trisubstituted phenylketo-enols for use as pesticides and herbicides BAYER AG (DE) 2007-08-14 US disclosed
US-7256158-B2 2,4,5,-trisubstituted phenylketo-enols for use as pesticides and herbicides BAYER AG (DE) 2007-08-14 US disclosed