Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033992 | 0.86 | POLB (0.68) | POLBMEN1KMT2AMAPTCYP2C9 | |
| SCHEMBL20569188 | 0.84 | TAAR1 (0.42) | POLBMEN1KMT2AMAPTCYP2C9 | |
| SCHEMBL14431723 | 0.82 | KMT2A (0.76) | POLBMEN1KMT2AMAPTCYP2C9 | |
| SCHEMBL4281294 | 0.81 | POLB (0.51) | POLBMEN1KMT2AMAPTCYP2C9 | |
| SCHEMBL27754661 | 0.78 | ALDH1A1 (0.47) | POLBMEN1KMT2AMAPTCYP2C9 | |
| SCHEMBL29283176 | 0.72 | ALDH1A1 (0.50) | POLBMEN1KMT2AMAPTCYP2C9 | |
| SCHEMBL4281747 | 0.71 | HSP90AA1 (0.56) | SIGMAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5256343 | 0.71 | SIGMAR1 (0.58) | POLBMEN1KMT2ATAAR1SIGMAR1 | |
| SCHEMBL29452905 | 0.71 | SMN1; SMN2 (0.49) | POLBMEN1KMT2AMAPTCYP2C9 | |
| SCHEMBL3038501 | 0.71 | SMN1; SMN2 (0.56) | POLBMEN1KMT2AMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490371-B1 | THIOPHENE-BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | BRISTOL MYERS SQUIBB CO (US) | 2007-08-15 | — | — | EP | disclosed |