Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849413 | 0.77 | MAOA (0.53) | MAPK1HPGDALOX15HSD17B10BRD4 | |
| SCHEMBL31332341 | 0.74 | SIGMAR1 (0.54) | ACHEMEN1ALDH1A1KMT2A | |
| SCHEMBL11882123 | 0.74 | TMPRSS2 (0.58) | MAPK1HPGDHSD17B10BRD4CREBBP | |
| SCHEMBL30252940 | 0.74 | MAPK1 (0.62) | MAPK1HPGDHSD17B10BRD4CREBBP | |
| SCHEMBL12533132 | 0.73 | MAPK1 (0.47) | MAPK1HPGDALOX15HSD17B10BRD4 | |
| SCHEMBL10280392 | 0.73 | MAPK1 (0.47) | MAPK1HPGDALOX15HSD17B10BRD4 | |
| SCHEMBL10241074 | 0.73 | MAPK1 (0.54) | MAPK1HPGDALOX15HSD17B10BRD4 | |
| SCHEMBL2818152 | 0.72 | MAPK1 (0.63) | MAPK1HPGDBRD4CREBBPAHR | |
| SCHEMBL379244 | 0.70 | MAPK1 (0.66) | MAPK1HPGDBRD4CREBBPAHR | |
| SCHEMBL11966963 | 0.70 | MAPK1 (0.58) | MAPK1HPGDALOX15HSD17B10BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294698-B1 | FUSED AZEPINE DERIVATIVES AND THEIR USE AS ANTIDIURETIC AGENTS | FERRING BV (NL) | 2007-08-01 | — | — | EP | disclosed |
| US-7176195-B2 | Fused azepine derivatives and their use as antidiuretic agents | FERRING BV (NL) | 2007-02-13 | — | — | US | disclosed |