Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430399 | 0.91 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AMAPTPARP14 | |
| SCHEMBL30522813 | 0.89 | TSHR (0.55) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13430401 | 0.87 | LMNA (0.55) | ALDH1A1LMNAMAPTPARP14PARP10 | |
| SCHEMBL12587775 | 0.84 | MAPT (0.53) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL13430394 | 0.81 | CHEK1 (0.58) | ALDH1A1MAPTDRD2KDM4ESMN1; SMN2 | |
| SCHEMBL14433465 | 0.81 | ALDH1A1 (0.53) | ALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL23002806 | 0.80 | HPGD (0.57) | ALDH1A1POLBTSHR | |
| SCHEMBL14433162 | 0.80 | ALDH1A1 (0.55) | ALDH1A1GAAHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL30522807 | 0.80 | ALDH1A1 (0.55) | ALDH1A1GAAHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL14433164 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056388-A9 | COMPOSITIONS AND METHODS FOR MODULATING POLY (ADP-RIBOSE) POLYMERASE ACTIVITY | GEN HOSPITAL CORP (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007056388-A2 | COMPOSITIONS AND METHODS FOR MODULATING POLY (ADP-RIBOSE) POLYMERASE ACTIVITY | THE GENERAL HOSPITAL CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20070105835-A1 | Compositions and methods for modulating poly(ADP-ribose) polymerase activity | THE GENERAL HOSPITAL CORPORATION | 2007-05-10 | — | — | US | disclosed |
| US-20070105835-A1 | Compositions and methods for modulating poly(ADP-ribose) polymerase activity | THE GENERAL HOSPITAL CORPORATION | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105835-A1 | Compositions and methods for modulating poly(ADP-ribose) polymerase activity | PARP1, PARP11, PARP2 | ALDH1A1 720/4885MEN1 3836/4885KMT2A 1385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.