SCHEMBL12587775

SCHEMBL12587775

COc1ccc(N2CCN(C(=O)c3ccc4c(c3)NC(=O)c3ccccc3S4)CC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.53
LMNA P02545 3/20 0.53
HPGD P15428 2/20 0.53
ALDH1A1 P00352 5/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
POLB P06746 2/20 0.52
PARP14 Q460N5 1/20 0.52
PARP10 Q53GL7 1/20 0.52
TP53 P04637 3/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
THRB P10828 1/20 0.50
BLM P54132 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
CDK5 Q00535 1/20 0.50
CDK5R1 Q15078 1/20 0.50
SMN1; SMN2 Q16637 4/20 0.49
KDM4E B2RXH2 1/20 0.48
HTT P42858 1/20 0.48
GAA P10253 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19776852 0.90 TP53 (0.60) MAPTLMNAHPGDALDH1A1MEN1
SCHEMBL12644135 0.89 CDK5 (0.56) MAPTLMNAHPGDALDH1A1MEN1
SCHEMBL13551001 0.88 LMNA (0.52) MAPTLMNAHPGDALDH1A1MEN1
SCHEMBL13464844 0.88 SMN1; SMN2 (0.60) MAPTLMNAHPGDMEN1KMT2A
SCHEMBL14433467 0.84 ALDH1A1 (0.54) MAPTLMNAALDH1A1MEN1KMT2A
SCHEMBL12644136 0.83 MAPT (0.53) MAPTLMNAHPGDALDH1A1POLB
SCHEMBL3897334 0.82 HPGD (0.60) MAPTLMNAHPGDALDH1A1MEN1
SCHEMBL12587800 0.82 KMT2A (0.61) MAPTMEN1KMT2ATP53CDK5
SCHEMBL12644134 0.80 LMNA (0.51) MAPTLMNAHPGDALDH1A1MEN1
SCHEMBL12644132 0.80 TP53 (0.55) MAPTLMNAHPGDALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346797-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-11-02 US disclosed
US-20230346797-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-11-02 US disclosed
EP-2696873-B1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA US HEALTH (US) 2022-08-03 EP disclosed
US-20210121476-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-04-29 US disclosed
US-20210085679-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-03-25 US disclosed
US-10881669-B2 Inhibitors of the plasmodial surface anion channel as antimalarials THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-01-05 US disclosed
US-10869865-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) 2020-12-22 US disclosed
US-20190183889-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) 2019-06-20 US disclosed
US-10265313-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2019-04-23 US disclosed
US-9974796-B2 Inhibitors of the plasmodial surface anion channel as antimalarials THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2018-05-22 US disclosed
US-20160193207-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2016-07-07 US disclosed
EP-2313100-B1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS US HEALTH (US) 2016-05-11 EP disclosed
US-9320786-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-04-26 US disclosed
US-20140088082-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS The U.S.A., as represented by the Secretary, Department of Health and Human Services. (US) 2014-03-27 US disclosed
US-20140088082-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS The U.S.A., as represented by the Secretary, Department of Health and Human Services. (US) 2014-03-27 US disclosed
US-20140079736-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2014-03-20 US disclosed
WO-2012142125-A2 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2012-10-18 WO disclosed
US-20110144086-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS The United States of America, as represented by the Secretary, Dept of Health and Human Service (US) 2011-06-16 US disclosed
US-20110144086-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS The United States of America, as represented by the Secretary, Dept of Health and Human Service (US) 2011-06-16 US disclosed
WO-2010011537-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2010-01-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346797-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885LMNA 624/4885HPGD 3034/4885
US-20140088082-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885LMNA 624/4885HPGD 3034/4885
US-10265313-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885LMNA 1159/4885HPGD 2538/4885
US-10869865-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885LMNA 1159/4885HPGD 2538/4885
US-20110144086-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, SLC9A1, CATSPER1 MAPT 2404/4885LMNA 563/4885HPGD 3000/4885
US-10881669-B2 Inhibitors of the plasmodial surface anion channel as antimalarials SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885LMNA 624/4885HPGD 3034/4885
US-20210121476-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885LMNA 624/4885HPGD 3034/4885
US-20140079736-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3435/4885LMNA 1059/4885HPGD 2691/4885
US-20210085679-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885LMNA 1159/4885HPGD 2538/4885
US-20160193207-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885LMNA 1159/4885HPGD 2538/4885
US-20190183889-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885LMNA 1159/4885HPGD 2538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.