Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.53 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.51 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.50 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785113 | 0.83 | SMN1; SMN2 (0.67) | EPHX2SAE1UBA2NPC1RAB9A | |
| SCHEMBL14434215 | 0.80 | ROCK2 (0.65) | ROCK2CNR1NPC1RAB9ANAMPT | |
| SCHEMBL10545814 | 0.77 | TAS1R3 (0.61) | ROCK2CNR1SAE1UBA2RAB9A | |
| SCHEMBL18695146 | 0.76 | NAMPT (0.64) | ROCK2SAE1UBA2NPC1RAB9A | |
| SCHEMBL14677618 | 0.75 | KDR (0.57) | EPHX2ROCK2CNR1RAB9ANAMPT | |
| SCHEMBL14433845 | 0.75 | MTOR (0.66) | ROCK2CNR1SAE1UBA2NAMPT | |
| SCHEMBL307447 | 0.75 | ROCK2 (0.68) | ROCK2CNR1SAE1UBA2NAMPT | |
| SCHEMBL14434586 | 0.75 | ROCK2 (0.67) | ROCK2CNR1RAB9ANAMPTLMNA | |
| SCHEMBL308998 | 0.74 | ROCK2 (0.73) | ROCK2CNR1SAE1UBA2NAMPT | |
| SCHEMBL306396 | 0.74 | ROCK2 (0.69) | ROCK2NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076055-A9 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED INC (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007076055-A2 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED, INC. (US) | 2007-07-05 | — | — | WO | disclosed |