Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | ALPG | P10696 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050574 | 0.93 | HPGD (0.73) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL4926246 | 0.85 | MEN1 (0.64) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11408582 | 0.84 | HPGD (0.73) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6965791 | 0.79 | LMNA (0.74) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14434222 | 0.76 | ALDH1A1 (1.00) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14433475 | 0.76 | LMNA (0.64) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7018134 | 0.75 | KMT2A (0.56) | HPGDMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL29481122 | 0.73 | IDO1 (0.79) | MEN1KMT2AALDH1A1MAPTMAOB | |
| SCHEMBL26991 | 0.73 | IDO1 (0.79) | MEN1KMT2AALDH1A1MAPTMAOB | |
| SCHEMBL18292385 | 0.73 | LMNA (1.00) | KMT2AALDH1A1MAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076055-A9 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED INC (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007076055-A2 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED, INC. (US) | 2007-07-05 | — | — | WO | disclosed |