Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14434333 | 0.82 | POLB (0.40) | POLBMAPK1PDE10AALDH1A1SMN1; SMN2 | |
| SCHEMBL27462527 | 0.78 | POLB (0.41) | POLBMAPK1LMNAALDH1A1HTT | |
| SCHEMBL14434338 | 0.78 | SMN1; SMN2 (0.47) | POLBMAPK1PDE10ALMNAALDH1A1 | |
| SCHEMBL28456316 | 0.75 | MAPK1 (0.43) | POLBMAPK1PDE10AALDH1A1SMN1; SMN2 | |
| SCHEMBL4161034 | 0.73 | LMNA (0.38) | POLBMAPK1LMNAHTTKDM4E | |
| SCHEMBL14434341 | 0.73 | NPSR1 (0.44) | MAPK1PDE10ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL11949168 | 0.73 | POLB (0.41) | POLBMAPK1PDE10ALMNAALDH1A1 | |
| SCHEMBL9704587 | 0.73 | POLB (0.55) | POLBMAPK1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1088195 | 0.73 | MAPK1 (0.48) | POLBMAPK1LMNAALDH1A1HTT | |
| SCHEMBL28396458 | 0.72 | LMNA (0.52) | POLBMAPK1LMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179125-A1 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179125-A1 | Aminopyrimidines useful as kinase inhibitors | ABL1, MAP3K5, MAP3K20 | POLB 782/4885MAPK1 214/4885PDE10A 2061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.