Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31518421 | 0.80 | ALDH1A1 (0.53) | POLBALDH1A1MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL17008019 | 0.80 | ALDH1A1 (0.53) | POLBALDH1A1MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL21906012 | 0.79 | POLB (0.52) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL30366735 | 0.76 | POLB (0.47) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL19878657 | 0.76 | POLB (0.47) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL19023262 | 0.75 | NPSR1 (0.41) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL8889049 | 0.75 | POLB (0.44) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL11949168 | 0.74 | POLB (0.41) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL27448979 | 0.74 | POLB (0.50) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL14434331 | 0.73 | POLB (0.48) | POLBALDH1A1MAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0482481-A1 | Method for the preparation of 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepines | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1992-04-29 | — | — | EP | disclosed |