Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP7 | Q93009 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435015 | 1.00 | MAPT (0.49) | MAPTPOLBARCHRNA7CA12 | |
| SCHEMBL14435016 | 1.00 | MAPT (0.49) | MAPTPOLBARCHRNA7CA12 | |
| SCHEMBL14435013 | 1.00 | MAPT (0.49) | MAPTPOLBARCHRNA7CA12 | |
| SCHEMBL14435011 | 0.86 | CHRNA7 (0.46) | MAPTARCHRNA7CA12CA1 | |
| SCHEMBL14435006 | 0.86 | CHRNA7 (0.46) | MAPTARCHRNA7CA12CA1 | |
| SCHEMBL14435020 | 0.80 | KIF11 (0.40) | MAPTPOLBGAA | |
| SCHEMBL14435023 | 0.80 | KIF11 (0.40) | MAPTPOLBGAA | |
| SCHEMBL14435009 | 0.78 | GAA (0.58) | MAPTGAAKDM4EALDH1A1TP53 | |
| SCHEMBL5516250 | 0.75 | CA12 (0.80) | MAPTPOLBARCHRNA7CA12 | |
| SCHEMBL5517723 | 0.75 | CA12 (0.80) | MAPTPOLBARCHRNA7CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179172-A1 | Positive modulators of nicotinic acetylcholine receptors | CHRNA1, CHRNA2, CHRM1 | MAPT 1307/4885POLB 4241/4885AR 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.