Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 3/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.38 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tianafac SCHEMBL2109723 | 0.78 | MAPT (0.67) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4380469 | 0.73 | MAPT (0.50) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7018255 | 0.72 | MAPT (0.59) | MAPTL3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6984802 | 0.71 | MAPT (0.54) | MAPTKDM4EL3MBTL1CMA1PFKFB3 | |
| SCHEMBL10091955 | 0.70 | MAPT (0.56) | MAPTKDM4EL3MBTL1CMA1PFKFB3 | |
| SCHEMBL11256326 | 0.68 | MAPT (0.54) | MAPTKDM4EL3MBTL1CMA1PFKFB3 | |
| SCHEMBL6659125 | 0.68 | MAPT (0.49) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28895381 | 0.68 | MAPT (0.45) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14218140 | 0.68 | MAPT (0.54) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6627880 | 0.67 | ALDH1A1 (0.43) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007098356-A1 | CONGENERS OF MILNACIPRAN AS MONOAMINE RE-UPTAKE | NEUROCRINE BIOSCIENCES, INC. (US) | 2007-08-30 | — | — | WO | disclosed |