Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.38 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928426 | 0.81 | CYP2A6 (0.41) | MAPTCYP2A6PIM1PIM2PFKFB3 | |
| SCHEMBL3926261 | 0.81 | KDM4E (0.41) | MAPTROCK1NPSR1L3MBTL1KDM4E | |
| SCHEMBL10091955 | 0.80 | MAPT (0.56) | MAPTROCK1NPSR1L3MBTL1KDM4E | |
| SCHEMBL11256326 | 0.78 | MAPT (0.54) | MAPTROCK1NPSR1L3MBTL1KDM4E | |
| Tianafac SCHEMBL2109723 | 0.77 | MAPT (0.67) | MAPTROCK1NPSR1L3MBTL1KDM4E | |
| SCHEMBL6118386 | 0.77 | ALDH1A1 (0.41) | MAPTROCK1L3MBTL1 | |
| SCHEMBL1253216 | 0.76 | MAPT (0.52) | MAPTROCK1NPSR1L3MBTL1KDM4E | |
| SCHEMBL1253215 | 0.76 | MAPT (0.56) | MAPTROCK1NPSR1L3MBTL1KDM4E | |
| SCHEMBL1254005 | 0.76 | ROCK1 (0.49) | MAPTROCK1NPSR1L3MBTL1KDM4E | |
| SCHEMBL4939687 | 0.74 | MCL1 (0.40) | MAPTNPSR1KDM4ECYP2A6TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |