Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | XIAP | P98170 | 1/20 | 0.51 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.51 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.47 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homophenylalanine SCHEMBL130567 | 0.84 | ALPI (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Homophenylalanine SCHEMBL44311 | 0.84 | ALPI (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Homophenylalanine SCHEMBL1078733 | 0.84 | ALPI (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Homophenylalanine SCHEMBL44312 | 0.84 | ALPI (0.64) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL8966420 | 0.83 | ALDH1A1 (0.50) | IDO1GRIK1SLC1A1ANPEPERAP1 | |
| SCHEMBL3859116 | 0.83 | SLC7A5 (0.70) | IDO1ALPIPKMPTGS1XIAP | |
| SCHEMBL5019164 | 0.83 | ALDH1A1 (0.50) | IDO1GRIK1SLC1A1ANPEPERAP1 | |
| SCHEMBL1245400 | 0.83 | ALDH1A1 (0.50) | IDO1GRIK1SLC1A1ANPEPERAP1 | |
| Homophenylalanine SCHEMBL2305748 | 0.83 | ALPI (0.62) | IDO1ALPIPKMPTGS1XIAP | |
| Homophenylalanine SCHEMBL1245414 | 0.83 | ALPI (0.62) | IDO1ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089745-A2 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R & D HOLDINGS, LLC (US) | 2007-08-09 | — | — | WO | disclosed |