Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.62 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 4/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15121585 | 1.00 | RORC (0.62) | RORCTACR1SIGMAR1MC4RDPP4 | |
| SCHEMBL1343829 | 1.00 | RORC (0.62) | RORCTACR1SIGMAR1MC4RDPP4 | |
| SCHEMBL1342948 | 1.00 | RORC (0.62) | RORCTACR1SIGMAR1MC4RDPP4 | |
| SCHEMBL12303419 | 0.92 | RORC (0.64) | RORCFUCA1GRIN2B | |
| SCHEMBL8089289 | 0.92 | RORC (0.64) | RORCFUCA1GRIN2B | |
| SCHEMBL8089286 | 0.92 | RORC (0.64) | RORCFUCA1GRIN2B | |
| SCHEMBL12303418 | 0.92 | RORC (0.64) | RORCFUCA1GRIN2B | |
| SCHEMBL3007011 | 0.89 | RORC (0.53) | RORCTACR1SIGMAR1DRD4DRD2 | |
| SCHEMBL3003822 | 0.89 | RORC (0.53) | RORCTACR1SIGMAR1DRD4DRD2 | |
| SCHEMBL7904084 | 0.89 | RORC (0.53) | RORCTACR1SIGMAR1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470524-B1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-07-24 | — | — | EP | disclosed |
| EP-2470524-A1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-07-04 | — | — | EP | disclosed |
| EP-2294063-A1 | PYRROLIDINE ETHER DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |
| WO-2011023626-A1 | PYRROLIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-03 | — | — | WO | disclosed |
| WO-2009150110-A1 | PYRROLIDINE ETHER DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-17 | — | — | WO | disclosed |