SCHEMBL14435896

SCHEMBL14435896

C#Cc1c(F)cc(C)cc1F

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SELL P14151 1/20 0.32
SELP P16109 1/20 0.32
SELE P16581 1/20 0.32
RAPGEF4 Q8WZA2 2/20 0.31
NFE2L2 Q16236 1/20 0.31
TRPV4 Q9HBA0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2336780 0.78 TRPV4 (0.33) TRPV4
SCHEMBL9793646 0.76 CYP1A1 (0.34) TRPV4
SCHEMBL13636536 0.75 AKR1C3 (0.35)
SCHEMBL13636627 0.74 CYP11B1 (0.34) NFE2L2
SCHEMBL13952767 0.74 PYCR1 (0.34) TRPV4
SCHEMBL31308688 0.74 TSHR (0.35) TRPV4
SCHEMBL18297701 0.74 TAAR1 (0.39) TRPV4
SCHEMBL80375 0.74 TRPV4 (0.58) TRPV4
SCHEMBL18297598 0.74 TRPV4 (0.31) TRPV4
SCHEMBL566436 0.74 SELL (0.32) SELLSELPSELERAPGEF4NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722156-B2 Liquid crystal compound and liquid crystal display INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2014-05-13 US disclosed
US-8722156-B2 Liquid crystal compound and liquid crystal display INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2014-05-13 US disclosed
US-20130235320-A1 LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL DISPLAY INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2013-09-12 US disclosed
US-20130235320-A1 LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL DISPLAY INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2013-09-12 US disclosed
US-8486497-B2 Liquid crystal compound, and liquid crystal display INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2013-07-16 US disclosed
US-20130100394-A1 LIQUID CRYSTAL COMPOUND, AND LIQUID CRYSTAL DISPLAY INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) 2013-04-25 US disclosed
EP-1813980-A1 LIQUID CRYSTAL DISPLAY DEVICE AND ELECTRONIC DEVICE HAVING THE SAME Sharp Kabushiki Kaisha (JP) 2007-08-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130100394-A1 LIQUID CRYSTAL COMPOUND, AND LIQUID CRYSTAL DISPLAY CCR3, C1S, CNOT1 SELL 2766/4885SELP 4639/4885SELE 4500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.