SCHEMBL14436331

SCHEMBL14436331

N#Cc1cc(C=Cc2ccc(N(c3ccccc3)c3ccc(O)cc3)cc2)c(C#N)cc1C=Cc1ccc(N(c2ccccc2)c2ccc(O)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 2/20 0.43
APP P05067 5/20 0.42
NPC1 O15118 2/20 0.40
MTOR P42345 2/20 0.40
PTPN1 P18031 1/20 0.40
MEN1 O00255 3/20 0.39
ALDH1A1 P00352 3/20 0.39
LMNA P02545 3/20 0.39
MAPT P10636 3/20 0.39
HPGD P15428 3/20 0.39
KMT2A Q03164 3/20 0.39
CA12 O43570 2/20 0.39
CA1 P00915 2/20 0.39
CA2 P00918 2/20 0.39
CA3 P07451 2/20 0.39
CA4 P22748 2/20 0.39
CA6 P23280 2/20 0.39
CA5A P35218 2/20 0.39
CA7 P43166 2/20 0.39
CA9 Q16790 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9915842 0.93 APP (0.46) APPALDH1A1MAPTHPGDKDM4E
SCHEMBL7716038 0.93 APP (0.46) APPALDH1A1MAPTHPGDKDM4E
SCHEMBL14436656 0.86 APP (0.44) NFE2L2APPNPC1ALDH1A1HPGD
SCHEMBL14436657 0.86 APP (0.44) NFE2L2APPNPC1ALDH1A1HPGD
SCHEMBL14436330 0.86 RELA (0.56) APPNPC1MEN1ALDH1A1LMNA
SCHEMBL12309963 0.84 APP (0.39) NFE2L2APPNPC1MTORMEN1
SCHEMBL23820710 0.83 APP (0.40) APPMEN1ALDH1A1MAPTHPGD
SCHEMBL7864805 0.83 APP (0.59) NFE2L2APPNPC1MTORMEN1
SCHEMBL28750226 0.83 APP (0.59) NFE2L2APPNPC1MTORMEN1
SCHEMBL28750228 0.83 APP (0.59) NFE2L2APPNPC1MTORMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7255935-B2 Organic electroluminescent element and luminescent apparatus employing the same SONY CORPORATION (JP) 2007-08-14 US disclosed