SCHEMBL14436656

SCHEMBL14436656

Cc1ccc(N(c2ccccc2)c2ccc(N(c3ccccc3)c3ccc(C=Cc4cc(C#N)c(C=Cc5ccc(N(c6ccccc6)c6ccc(N(c7ccccc7)c7ccc(C)cc7)cc6)cc5)cc4C#N)cc3)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
APP P05067 2/20 0.44
NFE2L2 Q16236 5/20 0.43
TRPM8 Q7Z2W7 2/20 0.41
PRKCQ Q04759 3/20 0.40
PRKCD Q05655 2/20 0.40
FGF23 Q9GZV9 1/20 0.40
RELA Q04206 1/20 0.40
HPGD P15428 2/20 0.39
ALDH1A1 P00352 1/20 0.39
ALOX12 P18054 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
KDM4E B2RXH2 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CTDSP1 Q9GZU7 1/20 0.36
SLC16A3 O15427 1/20 0.36
SLC16A1 P53985 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14436657 1.00 APP (0.44) APPNFE2L2TRPM8PRKCQPRKCD
SCHEMBL14437326 0.95 APP (0.41) APPNFE2L2TRPM8PRKCQPRKCD
SCHEMBL14436658 0.94 NFE2L2 (0.41) APPNFE2L2PRKCQPRKCDFGF23
SCHEMBL22017427 0.94 NFE2L2 (0.41) APPNFE2L2PRKCQPRKCDFGF23
SCHEMBL9915842 0.93 APP (0.46) APPPRKCQPRKCDRELAHPGD
SCHEMBL7716038 0.93 APP (0.46) APPPRKCQPRKCDRELAHPGD
SCHEMBL14436652 0.91 RELA (0.50) NFE2L2TRPM8RELAHPGDALDH1A1
SCHEMBL14436330 0.89 RELA (0.56) APPPRKCQPRKCDRELAALDH1A1
SCHEMBL14036456 0.88 APP (0.40) APPNFE2L2TRPM8PRKCQPRKCD
SCHEMBL13807869 0.88 APP (0.38) APPNFE2L2TRPM8PRKCQPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7255935-B2 Organic electroluminescent element and luminescent apparatus employing the same SONY CORPORATION (JP) 2007-08-14 US disclosed