Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.35 |
| ▸ | STK10 | O94804 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504200 | 0.88 | MAPK1 (0.36) | MEN1KMT2AMAPK1MAPTALDH1A1 | |
| SCHEMBL14437205 | 0.81 | EGFR (0.39) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13898543 | 0.80 | MEN1 (0.42) | MEN1KMT2AMAPK1MAPTALDH1A1 | |
| SCHEMBL13233381 | 0.80 | MEN1 (0.42) | MEN1KMT2AMAPK1MAPTALDH1A1 | |
| SCHEMBL14437230 | 0.80 | MEN1 (0.38) | MEN1KMT2AMAPK1MAPTALDH1A1 | |
| SCHEMBL2993546 | 0.79 | MEN1 (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL2993549 | 0.79 | MEN1 (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL14437241 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2AMAPK1MAPTALDH1A1 | |
| SCHEMBL4871699 | 0.78 | CDK1 (0.49) | MEN1KMT2AMAPK1MAPTALDH1A1 | |
| SCHEMBL4866405 | 0.78 | CDK1 (0.49) | MEN1KMT2AMAPK1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |