Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.56 |
| ▸ | MMP2 | P08253 | 6/20 | 0.52 |
| ▸ | MMP9 | P14780 | 6/20 | 0.52 |
| ▸ | MMP8 | P22894 | 6/20 | 0.52 |
| ▸ | MMP13 | P45452 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.52 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5251968 | 0.84 | NPC1 (0.59) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL4833915 | 0.81 | MMP2 (0.61) | MMP2MMP9MMP8MMP13NPC1 | |
| SCHEMBL5298807 | 0.81 | CHEK2 (0.59) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL4476782 | 0.80 | RAB9A (0.53) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL5217712 | 0.80 | CHEK2 (0.71) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL23675297 | 0.79 | MAP4K4 (0.47) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL984422 | 0.78 | RAB9A (0.59) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL14439825 | 0.78 | NPC1 (0.62) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL5217725 | 0.78 | CHEK2 (0.87) | CHEK2MMP2MMP9MMP8MMP13 | |
| SCHEMBL986061 | 0.76 | MMP13 (0.57) | MMP2MMP9MMP8MMP13NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |