Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | ACR | P10323 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15803989 | 0.86 | CA12 (0.52) | CA12CA1CA2CA9CA14 | |
| SCHEMBL176369 | 0.86 | CA12 (0.71) | CA12CA1CA2CA9CA14 | |
| SCHEMBL2909577 | 0.81 | CA12 (0.61) | CA12CA1CA2CA9CA14 | |
| SCHEMBL11410746 | 0.81 | CA12 (0.66) | CA12CA1CA2CA9CA14 | |
| Terephthalic Acid SCHEMBL28552075 | 0.80 | CA1 (0.65) | CA12CA1CA2CA9CA14 | |
| SCHEMBL2832918 | 0.79 | CA1 (0.63) | CA12CA1CA2CA9CA14 | |
| SCHEMBL570567 | 0.79 | LMNA (0.67) | CA12CA1CA2CA9CA14 | |
| SCHEMBL7872582 | 0.79 | CA12 (0.63) | CA12CA1CA2CA9CA14 | |
| SCHEMBL9960375 | 0.78 | CA1 (0.58) | CA12CA1CA2CA9CA14 | |
| SCHEMBL19762354 | 0.77 | ALDH1A1 (0.55) | NPC1MEN1KMT2AMAPTUSP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253158-B2 | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253158-B2 | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |