Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.41 |
| ▸ | CDK2 | P24941 | 6/20 | 0.41 |
| ▸ | CCNO | P22674 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458662 | 0.75 | BCHE (0.54) | SMN1; SMN2MAPTALDH1A1KDM4ERAB9A | |
| SCHEMBL1905339 | 0.69 | KDM5A (0.50) | SMN1; SMN2L3MBTL1MAPTALDH1A1THRB | |
| SCHEMBL10999884 | 0.67 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTALDH1A1PDCD1CD274 | |
| SCHEMBL20320460 | 0.67 | MAPK10 (0.46) | SMN1; SMN2L3MBTL1MAPTALDH1A1THRB | |
| SCHEMBL3461571 | 0.67 | MAPT (0.56) | SMN1; SMN2MAPTALDH1A1KDM4ERAB9A | |
| SCHEMBL18949733 | 0.67 | ALDH1A1 (0.55) | SMN1; SMN2L3MBTL1MAPTALDH1A1THRB | |
| SCHEMBL14446907 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1ALDH1A1PDCD1CD274 | |
| SCHEMBL14446911 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1PDCD1CD274EP300 | |
| SCHEMBL16887813 | 0.66 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1MAPTALDH1A1THRB | |
| SCHEMBL20320454 | 0.65 | MAPT (0.40) | SMN1; SMN2L3MBTL1MAPTALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-7183293-B2 | Ether derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC. (US) | 2007-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PDE4A, PDE4B, PDE4D | SMN1; SMN2 3836/4885L3MBTL1 3318/4885MAPT 4849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.