Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | OXTR | P30559 | 5/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1906271 | 0.84 | OXTR (0.40) | KDM5AKDM4CKDM5BOXTRAVPR1A | |
| SCHEMBL9697055 | 0.76 | RAB9A (0.44) | OXTRAVPR1ASMN1; SMN2RAB9AHPGD | |
| SCHEMBL8673827 | 0.76 | RAB9A (0.44) | OXTRAVPR1ASMN1; SMN2RAB9AMAPT | |
| SCHEMBL31023204 | 0.76 | POLB (0.57) | OXTRAVPR1ASMN1; SMN2RAB9AMAPT | |
| SCHEMBL544026 | 0.76 | POLB (0.57) | OXTRAVPR1ASMN1; SMN2RAB9AMAPT | |
| SCHEMBL26051421 | 0.76 | RAB9A (0.41) | OXTRAVPR1ASMN1; SMN2RAB9AMAPT | |
| SCHEMBL17086621 | 0.75 | KDM4C (0.57) | KDM5AKDM4CKDM5BSMN1; SMN2MAPT | |
| SCHEMBL22349328 | 0.73 | KDM5A (0.59) | KDM5AKDM4CKDM5BOXTRAVPR1A | |
| SCHEMBL3461571 | 0.73 | MAPT (0.56) | SMN1; SMN2RAB9AMAPTNPC1TP53 | |
| SCHEMBL12922843 | 0.73 | CYP17A1 (0.49) | KDM5AKDM4CKDM5BSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365592-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. | 2023-11-16 | — | — | US | disclosed |
| WO-2023164233-A1 | (4-BENZO[D]OXAZOL-2-YL)-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-5(4H)-YL)METHANONE DERIVATIVES AS MUTANT PAH STABILIZERS FOR THE TREATMENT OF PHENYLKETONURIA | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| US-20150094474-A1 | AGRICULTURAL CHEMICALS | REDAG CROP PROTECTION LTD (GB) | 2015-04-02 | — | — | US | disclosed |
| US-8455477-B2 | Therapeutic compounds | MERCK SHARP & DOHME CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110207711-A1 | Therapeutic Compounds | MSD K.K. (JP) | 2011-08-25 | — | — | US | disclosed |
| EP-2320907-A1 | THERAPEUTIC COMPOUNDS | Merck & Co., Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| US-7834186-B2 | Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-11-16 | — | — | US | disclosed |
| WO-2010017047-A1 | THERAPEUTIC COMPOUNDS | MERCK & CO., INC. (US) | 2010-02-11 | — | — | WO | disclosed |
| US-20090036686-A1 | PREPARATION AND USE OF 2-SUBSTITUTED-5-OXO-3-PYRAZOLIDINECARBOXYLATES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-02-05 | — | — | US | disclosed |
| US-7442799-B2 | reacting succinic acid derivatives with substituted hydrazines in presence of acid scavengers and solvents, to form chemical intermediates for benzoxazinones; cyclization | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-10-28 | — | — | US | disclosed |
| US-7339057-B2 | Method for preparing fused oxazinones from ortho-amino aromatic carboxylic acid and carboxylic acid in the presence of a sulfonyl chloride and pyridine | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-03-04 | — | — | US | disclosed |
| US-7276601-B2 | Method and preparing fused oxazinones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-02 | — | — | US | disclosed |
| US-20070021468-A1 | Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates | FMC CORPORATION | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094474-A1 | AGRICULTURAL CHEMICALS | DDT, SQOR, GPX4 | KDM5A 588/4885KDM4C 468/4885KDM5B 970/4885 |
| US-20110207711-A1 | Therapeutic Compounds | WEE2, MARK3, WEE1 | KDM5A 3655/4885KDM4C 3495/4885KDM5B 3757/4885 |
| US-20230365592-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | PAH, KDM8, PHF8 | KDM5A 32/4885KDM4C 126/4885KDM5B 99/4885 |
| US-20070021468-A1 | Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates | HRH2, OGDH, HRH1 | KDM5A 289/4885KDM4C 290/4885KDM5B 141/4885 |
| US-20090036686-A1 | PREPARATION AND USE OF 2-SUBSTITUTED-5-OXO-3-PYRAZOLIDINECARBOXYLATES | HRH2, HRH3, HRH1 | KDM5A 271/4885KDM4C 272/4885KDM5B 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.