Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14447473 | 0.88 | MAPT (0.49) | MAPTHTTTP53LMNAKDM4E | |
| SCHEMBL17109171 | 0.87 | USP2 (0.49) | MAPTHTTTP53LMNAKDM4E | |
| SCHEMBL12026565 | 0.84 | HTR2B (0.49) | MAPTHTTKDM4ETHRBSMN1; SMN2 | |
| SCHEMBL12026566 | 0.84 | MAPT (0.47) | MAPTHTTTP53LMNAKDM4E | |
| SCHEMBL1299150 | 0.84 | SMN1; SMN2 (0.52) | MAPTHTTTP53LMNAKDM4E | |
| SCHEMBL14447475 | 0.83 | LMNA (0.60) | MAPTHTTTP53LMNAPKM | |
| SCHEMBL992227 | 0.83 | HTR2B (0.59) | MAPTPKMPOLBSMN1; SMN2HPGDS | |
| SCHEMBL17115816 | 0.83 | HPGDS (0.51) | MAPTKDM4ETHRBSMN1; SMN2KMT2A | |
| SCHEMBL12026706 | 0.82 | MAPT (0.46) | MAPTHTTTP53LMNAKDM4E | |
| SCHEMBL2595515 | 0.81 | GPR119 (0.54) | MAPTKDM4ETHRBHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244847-B2 | Benzimidazole compounds | ISIS PHARMACEUTICALS, INC. (US) | 2007-07-17 | — | — | US | disclosed |