Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 7/20 | 0.45 |
| ▸ | UBA3 | Q8TBC4 | 6/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13192031 | 0.87 | NAE1 (0.44) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL10233932 | 0.86 | CA2 (0.46) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL10293821 | 0.86 | NAE1 (0.51) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL10235256 | 0.85 | PDE5A (0.46) | — | |
| SCHEMBL2740595 | 0.85 | METTL3 (0.49) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL10293817 | 0.84 | NAE1 (0.44) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL10242205 | 0.84 | NAE1 (0.49) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL2740590 | 0.81 | NAE1 (0.50) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL13194017 | 0.81 | NAE1 (0.47) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL2740568 | 0.80 | NAE1 (0.47) | NAE1UBA3CA2UBA6GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007092213-A2 | INHIBITORS OF E1 ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-08-16 | — | — | WO | disclosed |