Guanosine

Guanosine

SCHEMBL1444901

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=P(O)(O)S

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.69
HPGD P15428 1/20 0.68
TGM2 P21980 1/20 0.64
HINT1 P49773 4/20 0.61
PNP P00491 1/20 0.59
PAX8 Q06710 1/20 0.59
KRAS P01116 4/20 0.58
GSK3A P49840 2/20 0.58
RPS6KA3 P51812 2/20 0.58
MAPK14 Q16539 2/20 0.58
FUT5 Q11128 1/20 0.57
IMPDH2 P12268 2/20 0.56
IMPDH1 P20839 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL2589323 0.96 NT5E (0.72) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL1304255 0.96 NT5E (0.72) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL376138 0.96 NT5E (0.72) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL44407 0.96 NT5E (0.72) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL94793 0.96 NT5E (0.72) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL31361372 0.96 NT5E (0.72) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL5356557 0.95 NT5E (0.70) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL8719176 0.95 NT5E (0.70) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL9238739 0.94 NT5E (0.69) NT5EHPGDTGM2HINT1PNP
Guanosine SCHEMBL21315718 0.94 HPGD (0.71) NT5EHPGDTGM2HINT1PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7223538-B2 Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays GE HEALTHCARE BIO-SCIENCES AB (SE) 2007-05-29 US claimed
CN-1620515-A Post-synthesis labeling of nucleic acids and uses thereof AMERSHAM BIOSCIENCES AB (SE) 2005-05-25 CN claimed
EP-1461455-A2 POST-SYNTHESIS LABELING OF NUCLEIC ACIDS AND USES THEREOF Amersham Biosciences AB (SE) 2004-09-29 EP claimed
WO-2003052115-A2 POST-SYNTHESIS LABELING OF NUCLEIC ACIDS AND USES THEREOF AMERSHAM BIOSCIENCES AB (SE) 2003-06-26 WO claimed
US-20030119005-A1 Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays MOTOROLA, INC. 2003-06-26 US claimed
WO-2025068557-A1 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF CANAVAN DISEASE CONTERA PHARMA A/S (DK) 2025-04-03 WO disclosed
EP-3047026-B1 MULTIFUNCTIONAL RNA NANOPARTICLES AND METHODS OF USE THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 2021-08-18 EP disclosed
US-20210162066-A1 RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-06-03 US disclosed
US-20200199587-A1 FUNCTIONALLY-INTERDEPENDENT SHAPE SWITCHING NUCLEIC ACID NANOPARTICLES THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2020-06-25 US disclosed
EP-3354734-B1 OLIGONUCLEOTIDE-BASED INHIBITORS COMPRISING LOCKED NUCLEIC ACID MOTIF MIRAGEN THERAPEUTICS INC (US) 2020-06-10 EP disclosed
US-10517890-B2 Triggering RNA interference with RNA-DNA and DNA-RNA nanoparticles THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2019-12-31 US disclosed
US-20190192687-A1 RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICE (US) 2019-06-27 US disclosed
US-5962219-A DETECTING NUCLEIC ACIDS WITH ACTIVITY BY MIXING WITH TARGET, FORMING COVALENT BOND BETWEEN TARGET AND CHEMICALLY REACTIVE UNIT OF NUCLEIC ACID, SEPARATING NUCLEIC ACIDS WITH ACTIVITY FROM NONREACTIVE NUCLEIC ACIDS NEXSTAR PHARMACEUTICALS, INC. (US) 1999-10-05 US disclosed
US-5858660-A FORMING PRODUCT LIBRARY BY CONTACTING TWO OR MORE REACTANTS WHERE ONE REACTANT IS COUPLED TO NUCLEIC ACID CAPABLE OF MEDIATING BOND FORMATION, SELECTING PRODUCTS HAVING PREDETERMINED CHARACTERISTICS NEXSTAR PHARMACEUTICLAS, INC. (US) 1999-01-12 US disclosed
US-5763595-A NUCLEIC ACID LIGANDS WHICH BIND COVALENTLY WITH PROTEIN NEXSTAR PHARMACEUTICALS, INC. (US) 1998-06-09 US disclosed
EP-0840742-A1 SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: CHEMI-SELEX NeXstar Pharmaceuticals, Inc. (US) 1998-05-13 EP disclosed
US-5705337-A NUCLEIC ACID DETECTION OF LIGANDS THAT BIND COVALENTLY WITH TARGET MOLECULE COMPLEXES NEXSTAR PHARMACEUTICALS, INC. (US) 1998-01-06 US disclosed
EP-0782580-A1 PARALLEL SELEX NeXstar Pharmaceuticals, Inc. (US) 1997-07-09 EP disclosed
WO-1996027605-A1 SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: CHEMI-SELEX NEXSTAR PHARMACEUTICALS, INC. (US) 1996-09-12 WO disclosed
WO-1996009316-A1 PARALLEL SELEX NEXSTAR PHARMACEUTICALS, INC. (US) 1996-03-28 WO disclosed