Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | TGM2 | P21980 | 1/20 | 0.66 |
| ▸ | HINT1 | P49773 | 4/20 | 0.64 |
| ▸ | PNP | P00491 | 1/20 | 0.61 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.61 |
| ▸ | KRAS | P01116 | 4/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.60 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanosine SCHEMBL31361372 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL94793 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL1304255 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL2589323 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL44407 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL8719176 | 0.99 | NT5E (0.70) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL29220760 | 0.97 | NT5E (0.68) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL5356557 | 0.97 | NT5E (0.70) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL9238739 | 0.96 | NT5E (0.69) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL1444901 | 0.96 | NT5E (0.69) | NT5EHPGDTGM2HINT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 226 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024155027-A1 | ATTENUATED SALMONELLA GALLINARUM EXPRESSING FLIC OR FLIC-HIL2 AND USE THEREOF | 주식회사 오디세우스바이오 | 2024-07-25 | — | — | WO | claimed |
| US-20240240140-A1 | ATTENUATED SALMONELLA GALLINARUM EXPRESSING FLIC OR FLIC-HIL2 AND USES THEREOF | Odysseus Bio Co., Ltd. (KR) | 2024-07-18 | — | — | US | claimed |
| US-20240218318-A1 | ATTENUATED SALMONELLA GALLINARUM STRAIN AND USE THEREOF | Odysseus Bio Co., Ltd. (KR) | 2024-07-04 | — | — | US | claimed |
| US-20240108664-A1 | TUMOR-TARGETING SALMONELLA GALLINARUM STRAIN AND USE THEREOF | INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY (KR) | 2024-04-04 | — | — | US | claimed |
| EP-4332228-A1 | ATTENUATED SALMONELLA GALLINARUM STRAIN AND USE THEREOF | Industry Foundation of Chonnam National University (KR) | 2024-03-06 | — | — | EP | claimed |
| CN-117480255-A | Attenuated salmonella gallinarum strain and use thereof | 全南大学校产学协力团 | 2024-01-30 | — | — | CN | claimed |
| CN-114324540-B | Guanosine tetraphosphoric acid electrochemical nano-enzyme sensor and preparation method thereof | 天津商业大学 | 2023-12-26 | — | — | CN | claimed |
| CN-115943211-A | Tumor-targeted salmonella gallinarum strain and application thereof | 全南大学校产学协力团 | 2023-04-07 | — | — | CN | claimed |
| CN-115844804-A | Composition for improving exogenous aging and preparation method and application thereof | 湖北省吉美化妆品有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-115813803-A | Composition capable of improving skin anti-wrinkle, moisturizing and whitening effects on cell layer | 广州时光之城科技有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-110243964-A | In a kind of water treatment technology in microbial body guanosine tetraphosphate HPLC detection method | 西安建筑科技大学 | 2019-09-17 | — | — | CN | claimed |
| CN-109932439-A | A kind of ultra performance liquid chromatography detection method of guanosine tetraphosphate | 中国农业大学 | 2019-06-25 | — | — | CN | claimed |
| US-20190169630-A1 | IMPROVEMENT OF PHOTOSYNTHETIC ORGANISMS THROUGH THE MODULATION OF GUANOSINE TETRAPHOSPHATE HOMEOSTATIS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS ) (FR) | 2019-06-06 | — | — | US | claimed |
| EP-3414332-A1 | IMPROVEMENT OF PHOTOSYNTHETIC ORGANISMS THROUGH THE MODULATION OF GUANOSINE TETRAPHOSPHATE HOMEOSTATIS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-12-19 | — | — | EP | claimed |
| WO-2017137374-A1 | IMPROVEMENT OF PHOTOSYNTHETIC ORGANISMS THROUGH THE MODULATION OF GUANOSINE TETRAPHOSPHATE HOMEOSTATIS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - (FR) | 2017-08-17 | — | — | WO | claimed |
| US-20150366777-A1 | COMBINATION OF SKIN PROTECTION AGAINST DAMAGES CAUSED BY INFRARED RADIATION | HYPERMARCAS S.A. (BR) | 2015-12-24 | — | — | US | claimed |
| US-6562801-B1 | PpGpp and pppGpp as immunomodulatory agents | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-05-13 | — | — | US | claimed |
| US-20030039657-A1 | Inducible vaccines | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-02-27 | — | — | US | claimed |
| WO-2000062803-A2 | ppGpp AND pppGpp AS IMMUNOMODULATORY AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-10-26 | — | — | WO | claimed |
| WO-2000062817-A2 | INDUCIBLE VACCINES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-10-26 | — | — | WO | claimed |