Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | TGM2 | P21980 | 1/20 | 0.66 |
| ▸ | HINT1 | P49773 | 4/20 | 0.64 |
| ▸ | PNP | P00491 | 1/20 | 0.61 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.61 |
| ▸ | KRAS | P01116 | 4/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.60 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanosine SCHEMBL31361372 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL94793 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL376138 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL2589323 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL44407 | 1.00 | NT5E (0.72) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL8719176 | 0.99 | NT5E (0.70) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL29220760 | 0.97 | NT5E (0.68) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL5356557 | 0.97 | NT5E (0.70) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL9238739 | 0.96 | NT5E (0.69) | NT5EHPGDTGM2HINT1PNP | |
| Guanosine SCHEMBL1444901 | 0.96 | NT5E (0.69) | NT5EHPGDTGM2HINT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025231164-A2 | ENGINEERED PLANT MICROORGANISMS FOR RNAi DELIVERY AND USES THEREOF | ROBIGO, INC. (US) | 2025-11-06 | — | — | WO | claimed |
| US-20150366777-A1 | COMBINATION OF SKIN PROTECTION AGAINST DAMAGES CAUSED BY INFRARED RADIATION | HYPERMARCAS S.A. (BR) | 2015-12-24 | — | — | US | claimed |
| US-6562801-B1 | PpGpp and pppGpp as immunomodulatory agents | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-05-13 | — | — | US | claimed |
| US-20030039657-A1 | Inducible vaccines | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2003-02-27 | — | — | US | claimed |
| WO-2000062803-A2 | ppGpp AND pppGpp AS IMMUNOMODULATORY AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-10-26 | — | — | WO | claimed |
| WO-2000062817-A2 | INDUCIBLE VACCINES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-10-26 | — | — | WO | claimed |
| US-20260128119-A1 | SCREENING METHODS FOR ACINETOBACTER BAUMANNII SPOT ENZYME MODULATORS | Université Libre de Bruxelles (BE) | 2026-05-07 | — | — | US | disclosed |
| EP-4696775-A1 | NOVEL VARIANT OF (P)PPGPP SYNTHETASE AND METHOD FOR PRODUCING 5?-INOSINIC ACID USING SAME | Daesang Corporation (KR) | 2026-02-18 | — | — | EP | disclosed |
| WO-2025231164-A2 | ENGINEERED PLANT MICROORGANISMS FOR RNAi DELIVERY AND USES THEREOF | ROBIGO, INC. (US) | 2025-11-06 | — | — | WO | disclosed |
| US-20250297298-A1 | FERMENTATION PROCESS INTENDED TO PRODUCE METABOLITES WITH EPIGENETIC PROPERTIES USING BACTERIA EVOLVED IN THE EXTREME CONDITIONS OF SPACE | INNOVATION LABO SCIENCES CO LTD (JP) | 2025-09-25 | — | — | US | disclosed |
| EP-4605090-A1 | SCREENING METHODS FOR ACINETOBACTER BAUMANNII SPOT ENZYME MODULATORS | Université Libre de Bruxelles (BE) | 2025-08-27 | — | — | EP | disclosed |
| US-20250223542-A1 | MODIFIED MICROALGAE FOR ENHANCED PHOSPHATE UPTADE INVOLVING OVEREXPRESSION OF PSR1 AND OPTIONALLY UNDEREXPRESSION OF PTC1 | INSTITUTE OF AGRICULTURAL RESOURCES AND REGIONAL PLANNING OF THE CHINESE ACADE (CN) | 2025-07-10 | — | — | US | disclosed |
| CN-118360353-B | Method for improving thaxtomin A yield through Streptomyces scab relA gene | 安徽农业大学 | 2025-04-08 | — | — | CN | disclosed |
| WO-1999051766-A1 | METHODS FOR PRODUCING LIBRARIES OF EXPRESSIBLE GENE SEQUENCES | INVITROGEN CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999051620-A1 | LIBRARIES OF EXPRESSIBLE GENE SEQUENCES | INVITROGEN CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1998035054-A1 | METHODS FOR SCREENING FOR ANTIBIOTICS | RIBOGENE, INC. (US) | 1998-08-13 | — | — | WO | disclosed |
| EP-0385936-A1 | Peptide lactone and derivatives thereof, process for their production and means for carrying out the process | CIBA-GEIGY AG (CH) | 1990-09-05 | — | — | EP | disclosed |
| US-4152209-A | CULTIVATING A STRAIN OF STREPTOMYCES OR STREPTOVERTICILLIUM | SANRAKU-OCEAN CO., LTD. (JP) | 1979-05-01 | — | — | US | disclosed |
| US-4141972-A | Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and processes for their preparation | SANRAKU-OCEAN CO., LTD. (JP) | 1979-02-27 | — | — | US | disclosed |
| US-4059487-A | Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and processes for their preparation | SANRAKU-OCEAN CO., LTD. (JA) | 1977-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260128119-A1 | SCREENING METHODS FOR ACINETOBACTER BAUMANNII SPOT ENZYME MODULATORS | STUB1, PPME1, BPGM | NT5E 2350/4885HPGD 3182/4885TGM2 938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.