Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676858 | 0.84 | CYP11B2 (0.51) | CYP11B2CYP11B1PRKCZADRA2AADRA2B | |
| SCHEMBL17689700 | 0.81 | CYP11B1 (0.47) | CYP11B2CYP11B1HTR2C | |
| SCHEMBL19337235 | 0.78 | PRKCZ (0.45) | CYP11B2CYP11B1PRKCZCNR1CNR2 | |
| SCHEMBL20873066 | 0.78 | PRKCZ (0.64) | CYP11B2CYP11B1PRKCZADRA2AADRA2B | |
| SCHEMBL10601314 | 0.76 | MAPK9 (0.43) | EGFRCYP2D6 | |
| SCHEMBL12428417 | 0.76 | CYP11B2 (0.51) | CYP11B2CYP11B1PRKCZCNR1CNR2 | |
| SCHEMBL2300302 | 0.76 | CYP11B2 (0.51) | CYP11B2CYP11B1PRKCZCNR1CNR2 | |
| SCHEMBL12386965 | 0.76 | CYP11B2 (0.51) | CYP11B2CYP11B1PRKCZCNR1CNR2 | |
| SCHEMBL30359418 | 0.76 | PRKCZ (0.53) | CYP11B2CYP11B1PRKCZADRA2AADRA2B | |
| SCHEMBL14725237 | 0.76 | MAPK9 (0.38) | EGFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480235-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | University Of Louisville Research Foundation, Inc. (US) | 2012-08-01 | — | — | EP | claimed |
| WO-2011038234-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2011-03-31 | — | — | WO | claimed |