⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12489486 | 0.79 | LMNA (0.33) | — | |
| SCHEMBL5625371 | 0.77 | AKR1C4 (0.31) | — | |
| SCHEMBL3275456 | 0.77 | AKR1C4 (0.31) | — | |
| SCHEMBL19716095 | 0.75 | LMNA (0.31) | — | |
| SCHEMBL1445033 | 0.70 | TLR4 (0.33) | — | |
| SCHEMBL3274371 | 0.70 | LMNA (0.33) | — | |
| SCHEMBL17510318 | 0.70 | LMNA (0.33) | — | |
| SCHEMBL5937607 | 0.67 | TDP1 (0.32) | — | |
| SCHEMBL3660712 | 0.67 | LMNA (0.32) | — | |
| SCHEMBL3278691 | 0.67 | L3MBTL1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480549-B1 | Fused imidazo[3,2-d]pyrazines as PI3 kinase inhibitors | FUNDACIÓN CT NAC DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2015-04-08 | — | — | EP | disclosed |
| US-20130029967-A1 | Fused Imidazo [3,2 - D] Pyrazines as P13 Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2013-01-31 | — | — | US | disclosed |
| EP-2480549-A1 | FUSED IMIDAZO [3, 2 - D]PYRAZINES AS PI3 KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011036461-A1 | FUSED IMIDAZO [3, 2 - D] PYRAZINES AS PI3 KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCΌLOGICAS (CNIO) (ES) | 2011-03-31 | — | — | WO | disclosed |