Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16733331 | 0.83 | ACE (0.33) | — | |
| SCHEMBL2869309 | 0.83 | ACE (0.33) | — | |
| SCHEMBL17495292 | 0.75 | MAPK1 (0.39) | LMNAMAPT | |
| SCHEMBL12151736 | 0.75 | LMNA (0.33) | LMNAMAPT | |
| SCHEMBL17510318 | 0.75 | LMNA (0.33) | LMNAMAPT | |
| SCHEMBL3274371 | 0.75 | LMNA (0.33) | LMNAMAPT | |
| SCHEMBL3278691 | 0.72 | L3MBTL1 (0.35) | MAPT | |
| SCHEMBL3275456 | 0.71 | AKR1C4 (0.31) | — | |
| SCHEMBL2487318 | 0.71 | LMNA (0.34) | LMNAMAPTPOLB | |
| SCHEMBL5625371 | 0.71 | AKR1C4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190428-A1 | HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck Sharp & Dohme Corp. (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009025784-A1 | HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2009-02-26 | — | — | WO | disclosed |