Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 15/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30463614 | 1.00 | MAPK1 (0.53) | MAPK1ADORA2BADORA1ADORA2AKDM4E | |
| SCHEMBL28135936 | 0.84 | ADORA2B (0.53) | ADORA2BADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL3061780 | 0.79 | ADORA2B (0.54) | ADORA2BADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL30463555 | 0.79 | ADORA2B (0.46) | MAPK1ADORA2BADORA1ADORA2AKDM4E | |
| SCHEMBL337077 | 0.76 | — | — | |
| SCHEMBL28758987 | 0.76 | ADORA2B (0.51) | MAPK1ADORA2BADORA1ADORA2AKDM4E | |
| SCHEMBL4057562 | 0.76 | ADORA2B (0.61) | ADORA2BADORA1ADORA2AADORA3MAP4K4 | |
| SCHEMBL3058599 | 0.76 | ADORA2B (0.57) | ADORA2BADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL3063758 | 0.76 | ADORA2B (0.54) | ADORA2BADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL29836037 | 0.75 | KDM4E (0.73) | MAPK1ADORA2AKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109400591-B | 4- (2-furyl) pyrimidine compound and preparation method and application thereof | 西华大学 | 2022-01-14 | — | — | CN | claimed |
| CN-109400591-A | 4- (2- furyl) pyrimidines and its preparation method and application | 西华大学 | 2019-03-01 | — | — | CN | claimed |
| EP-2480235-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | University Of Louisville Research Foundation, Inc. (US) | 2012-08-01 | — | — | EP | claimed |
| WO-2011038234-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2011-03-31 | — | — | WO | claimed |
| EP-3362451-B1 | INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2023-04-12 | — | — | EP | disclosed |
| CN-109400591-B | 4- (2-furyl) pyrimidine compound and preparation method and application thereof | 西华大学 | 2022-01-14 | — | — | CN | disclosed |
| CN-109400591-B | 4- (2-furyl) pyrimidine compound and preparation method and application thereof | 西华大学 | 2022-01-14 | — | — | CN | disclosed |
| CN-109400591-B | 4- (2-furyl) pyrimidine compound and preparation method and application thereof | 西华大学 | 2022-01-14 | — | — | CN | disclosed |
| US-10233173-B2 | Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators | JANSSEN PHARMACEUTICA NV (BE) | 2019-03-19 | — | — | US | disclosed |
| CN-109400591-A | 4- (2- furyl) pyrimidines and its preparation method and application | 西华大学 | 2019-03-01 | — | — | CN | disclosed |
| CN-109400591-A | 4- (2- furyl) pyrimidines and its preparation method and application | 西华大学 | 2019-03-01 | — | — | CN | disclosed |
| CN-109400591-A | 4- (2- furyl) pyrimidines and its preparation method and application | 西华大学 | 2019-03-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233173-B2 | Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators | GRIN3A, GRIN3B, GRIN1 | MAPK1 1716/4885ADORA2B 577/4885ADORA1 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.