Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | RHOC | P08134 | 2/20 | 0.46 |
| ▸ | RHOA | P61586 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863505 | 0.85 | LMNA (0.50) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL4278127 | 0.85 | CXCR3 (0.56) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL19112788 | 0.84 | LMNA (0.49) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL4277997 | 0.84 | CXCR3 (0.55) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL19113042 | 0.84 | EPHX2 (0.54) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL4273193 | 0.83 | CXCR3 (0.46) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL6863335 | 0.83 | STS (0.56) | CXCR3EPHX2TACR1 | |
| SCHEMBL4271452 | 0.83 | CXCR3 (0.54) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL6862660 | 0.82 | CXCR3 (0.48) | LMNACXCR3ACP1EPHX2NAMPT | |
| SCHEMBL12004810 | 0.82 | CXCR3 (0.53) | LMNACXCR3ACP1EPHX2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011032291-A1 | SELECTIVE CALCIUM CHANNEL MODULATORS | ZALICUS PHARMACEUTICALS LTD . (CA) | 2011-03-24 | — | — | WO | disclosed |