Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.88 |
| ▸ | PDE4A | P27815 | 9/20 | 0.88 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.88 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.88 |
| ▸ | PDE5A | O76074 | 4/20 | 0.57 |
| ▸ | PDE1A | P54750 | 2/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.56 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piclamilast SCHEMBL26573 | 0.94 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7335911 | 0.93 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7359687 | 0.89 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7341113 | 0.86 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7336534 | 0.86 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7336538 | 0.86 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7332633 | 0.85 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7354173 | 0.85 | PDE4D (0.83) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7341572 | 0.84 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| Piclamilast SCHEMBL2723503 | 0.84 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1813284-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-08-01 | — | — | EP | disclosed |