Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14456807 | 0.90 | S1PR5 (0.63) | TP53SMN1; SMN2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL14456812 | 0.89 | CYP3A4 (0.56) | CYP3A4CYP2D6KDM4EALDH1A1KMT2A | |
| SCHEMBL14456754 | 0.88 | KMT2A (0.63) | TP53SMN1; SMN2CYP3A4CYP2D6KDM4E | |
| SCHEMBL14456892 | 0.86 | MEN1 (0.63) | CYP3A4CYP2D6ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL14456766 | 0.85 | CYP3A4 (0.67) | CYP3A4CYP2D6KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14456779 | 0.85 | CYP3A4 (0.51) | CYP3A4CYP2D6KDM4EALDH1A1KMT2A | |
| SCHEMBL14456815 | 0.83 | TP53 (0.60) | TP53SMN1; SMN2CYP3A4CYP2D6KMT2A | |
| SCHEMBL14456755 | 0.83 | CYP3A4 (0.65) | SMN1; SMN2CYP3A4CYP2D6KDM4EALDH1A1 | |
| SCHEMBL14456826 | 0.83 | L3MBTL1 (0.57) | CYP3A4CYP2D6L3MBTL1KMT2A | |
| SCHEMBL14456786 | 0.82 | MEN1 (0.63) | CYP3A4CYP2D6KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |