Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | GRK5 | P34947 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144561 | 0.90 | PDGFRB (0.56) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL148479 | 0.89 | PDGFRB (0.51) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL140610 | 0.86 | KDR (0.70) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL144114 | 0.85 | AURKA (0.44) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL142711 | 0.84 | KDR (0.71) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL146226 | 0.84 | GRK5 (0.59) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL142147 | 0.82 | PRKAA1 (0.54) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL143571 | 0.82 | ALK (0.63) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL144186 | 0.80 | FGFR1 (0.55) | KDRPDGFRBFGFR1PRKAA1PRKAA2 | |
| SCHEMBL13711988 | 0.80 | KDR (0.66) | KDRPDGFRBFGFR1PRKAA1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | VERVA PHARMACEUTICALS PTY LTD (AU) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | FGF1, FABP4, FGF2 | KDR 1077/4885PDGFRB 467/4885FGFR1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.