Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16156942 | 0.87 | MEN1 (0.41) | MEN1KMT2APTPN1NR1D1THRB | |
| SCHEMBL4371396 | 0.85 | KMT2A (0.45) | MEN1KMT2ATHRBCA1CA2 | |
| SCHEMBL16156921 | 0.83 | THRB (0.39) | MEN1KMT2APTPN1NR1D1THRB | |
| SCHEMBL14476195 | 0.83 | MEN1 (0.52) | MEN1KMT2ATHRBCA1CA2 | |
| SCHEMBL25353748 | 0.83 | CA1 (0.46) | MEN1KMT2APTPN1CA1CA2 | |
| SCHEMBL14458721 | 0.80 | PTPN1 (0.36) | MEN1KMT2APTPN1NR1D1HSD11B1 | |
| SCHEMBL25228512 | 0.80 | SLC10A6 (0.43) | MEN1KMT2APTPN1THRBCA1 | |
| SCHEMBL30517731 | 0.80 | CA1 (0.43) | MEN1KMT2APTPN1CA1CA2 | |
| SCHEMBL24179552 | 0.79 | CA1 (0.45) | MEN1KMT2APTPN1NR1D1THRB | |
| SCHEMBL14163378 | 0.78 | NPY5R (0.52) | MEN1KMT2ATHRBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155731-A1 | Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155731-A1 | Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity | CCR2, ACKR3, CCR7 | MEN1 3332/4885KMT2A 4098/4885PTPN1 1249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.